Ngokungafani neminye imithi yokugoma eminingi equkethe igciwane elithathelwanayo noma ingxenye yalo, imigomo ye-viral vector isebenzisa igciwane elingenangozi ukuletha ucezu lwekhodi yofuzo kumaseli ethu, okuwavumela ukuthi enze iphrotheni ye-pathogen.Lokhu kuqeqesha amasosha ethu omzimba ukuthi asabele ezifweni ezizayo.
Uma sinokutheleleka kwebhaktheriya noma igciwane, amasosha ethu omzimba asabela kuma-molecule avela ku-pathogen.Uma kungokokuqala ngqa ukuhlangana nomhlaseli, izinqubo ezishunwe kahle ziyahlangana ukuze zilwe ne-pathogen futhi zakhe ukungatheleleki kokuhlangana nazo esikhathini esizayo.
Imithi yokugoma eminingi yesintu iletha i-pathogen ethathelwanayo noma ingxenye yayo emizimbeni yethu ukuze iqeqeshe amasosha ethu omzimba ukuze alwe nokuchayeka esikhathini esizayo ku-pathogen.
Imithi yokugomela i-viral vector isebenza ngendlela ehlukile.Basebenzisa igciwane elingenangozi ukuletha ucezu lwekhodi yofuzo lusuka ku-pathogen luye kumaseli ethu ukulingisa ukutheleleka.Igciwane elingenangozi lisebenza njengesistimu yokulethwa, noma i-vector, ngokulandelana kwezakhi zofuzo.
Amaseli ethu abe esekhiqiza iphrotheni yegciwane noma yebhaktheriya elethwe yi-vector futhi ayilethe emasosheni ethu omzimba.
Lokhu kusivumela ukuthi sihlakulele impendulo ethile yokuzivikela komzimba ngokumelene ne-pathogen ngaphandle kwesidingo sokuba nokutheleleka.
Kodwa-ke, i-viral vector ngokwayo idlala indima eyengeziwe ngokukhulisa ukuphendula kwethu kwamasosha omzimba.Lokhu kuholela ekuphenduleni okuqinile kunalapho ukulandelana kofuzo lwe-pathogen kwahanjiswa ngokwalo.
Umuthi wokugomela i-Oxford-AstraZeneca COVID-19 usebenzisa i-chimpanzee evame ukubanda ivector yegciwane eyaziwa ngokuthi i-ChAdOx1, eletha ikhodi evumela amaseli ethu ukuthi enze i-SARS-CoV-2 spike protein.
Isikhathi sokuthumela: Mar-24-2021